CONTRIBUTION TO THE STUDY OF THE ANTI-INFLAMMATORY ACTION MECHANISM FROM NATURAL EXTRACT OF Mangifera indica L. (VIMANG®)

Abstract

This thesis is linked to inflammation and the pharmacology of natural products. Ethnomedical knowledge originated in Cuba with the Mangifera indica L. species served as the basis for the Center for Pharmaceutical Chemistry obtained a standardized aqueous extract of the bark of this species, which was commercializes under the Registered Trademark VIMANG®. In investigations carried out it was possible to show that said extract has a powerful antioxidant action, as well as an immunomodulatory effect and that within the polyphenols present in the mixture, mangiferin is found in a higher proportion. Based on this background, it was considered It is necessary to study the anti-inflammatory effect of said extract, as well as to delve into the mechanisms involved in said action and the role played by its majority component. The thesis consists of 98 pages and its structure includes an introduction, five chapters, references bibliographic and other information. The Introduction addresses in six pages in a synthetic way, both the state of the art of the inflammatory process as well as the research and development of anti-inflammatory compounds. The hypothesis is also raised, two objectives general and three specific objectives in a clear and precise way, aimed at the study of Mangifera extract indicates L. as an anti-inflammatory agent and the elucidation of its mechanism of action.