Efecto del acido hialuronico en la cicatrizacion de heridas

Abstract

A hyaluronic acid (HA) crude extracted from the umbilical cord of human placentae was pharmacologically assessed as healing jelly. The experimental design used 20 adult female rats as biological model. Four wounds were made to each animal using disposable cutaneous biotomes of 9 mm. Treatments applied were: control (C), placebo (P), silver sulfadiazine (SS) and HA at 4%. Animals were treated for 7 days and there was a daily clinical control of the wounds. The product evaluated (HA) showed a better response regarding the remaining treatments with the healing of 70% of the wounds in the epithelial migration. Also it controlled the dermal renewal by 50% in the II degree and by 20% in the III degree demonstrating a matrix with collagenous fibres more mature than the rest. In the planimetry study this treatment was also of best evolution with 89.33% of re-epithelialized area, a shorter wound perimeter with 10.32 mm and larger lineal growth with 5.5 mm and a circularity lower than 61.33. It is concluded that the hyaluronic acid jelly at 4% is a medication that contributes to hasten the healing of the biomodel assayed.