Experimental models for the evaluation of active drug substances on atopic dermatitis

Abstract

Atopic dermatitis is a skin multifactorial inflammatory disease, which triggered as result of, environmental factors and genetic susceptibility interaction. In recent years, it has been shown that there are different experimental models capable of reproducing this disease and using the knowledge of pathophysiological aspects of the pathology and elucidating the action mechanisms of new treatments to evaluate. Therefore, the objective of this review work is to describe some of the experimental models used for the study of atopic dermatitis. For this, all the published information that was available in the PubMed data base was collected. This review provides a preview of scientific progress that links the species of laboratory animal used, the type of inducing agent and the possible responses obtained that reflect the clinical manifestations of the disease. The use fullness of animal models undoubtedly constitutes a fundamental tool for the scientific search and knowledge of atopic dermatitis. It is concluded that this document provides updated information regarding the various animal models most used in atopic dermatitis, which constitutes a consult tool for scientific research on this subject.