APPLICATION OF MULTIVARIATE CALIBRATION IN ANALYTICAL CHEMISTRY

Abstract

In the instrumental methods of analysis, tbe study of calibration is a paramowu aspect because it allows quantitative es­timation of analyte concentration. Traditionally the classic un­varied calibration is used. In the last decade an increasing number of papers related 10 the use of Multivaried Calibration have been publishe:I mainly in the fields of Atomic and Molecular Spectros::o­pies. Multiva·ied technique, allows the simulta1eous inclusion of mul­tiple analytical signals that can increase precision, accuracy and applicibiliry of analytical methods. The presem paper show.; methodo­logic:al criteria for the appliaition of Multiva-ied Calibráion Methods which are exemplififfl with data from literature and trom author's laboratory .An analysis is done in orderto select the-view, models and more appropriate methods. The following techniques are compara:!: Multiple Linear Regre$iOn, Principal Compom:ms Regre$iOn and Partía! Least Squares for the treatment of I ine¡r- models. Statistiml cri­teria are sugges;ed for tbe selection of the best calibrationmodel.